Q: I have terrible dry eyes and mouth, but my blood work is normal. Is it possible to have Sjogren’s syndrome and still have normal blood tests?
A: patients can have immune-related Sjogren’s syndrome with normal immune testing. However, the overwhelming majority have autoantibodies. Patients with negative tests should be evaluated for the administration of drugs known to produce dryness or viruses associated withsicca syndrome (e.g. hepatitis). In these situations, a salivary gland biopsy or imaging studies can confirm the diagnosis.
Source: Moisture Seekers April 2003